Lucia baquedano nacio en pamplona, espana, en 1938. Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer. Benign lesions of the cervix the belgian society of. Use of oral contraceptives usually focal, superficial glands. Arias is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms arias what does arias stand for. The arias stella reaction asr is a common and universally recognized feature of gestational endometrium.
After earning his doctorate from the san marcos national university, arias stella began his career as a pathology lecturer at the same institution, eventually rising to the senior lecturer position. The ariasstella reaction is a hormonerelated atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism, enlargement, and hyperchromasia. Request pdf ariasstella reaction in a cervicovaginal smear of a woman undergoing infertility treatment. Identical changes can be seen in an ectopic pregnancy. Arias estella gonadotropina gonadotropina corionica humana. Pseudoneoplastic glandular response of the female genital tract, first described by javier ariasstella in 1954 as atypical endometrial changes. A search in scielo and pubmed databases using the mesh terms arias stella reaction, endometriosis and adenocarcinoma was done. Ariasstella reaction is due to progesterone primarily. This glandular change is a physiologic response to the presence of chorionic tissue and is probably not directly related to trisomy 5. Cove 37 and rhatigan 38 have described cases of endocervical ariasstella reaction that caused confusion with premalignant or malignant conditions.
Glandulas revestidas por celulas secretoras en tachuela. We report a case of a 31 yearsold female previously treated with. Problem the presence of immunosuppressive cells within the endometrium and decidua is crucial for establishing maternal immune tolerance against fetal antigens. Departments of gynaecology and pathology, university of glasgow. Content is available under attributionnoncommercialsharealike 4. Pseudoneoplastic glandular response of the female genital tract, first described by javier ariasstella in 1954 as atypical endometrial changes associated with the presence of chorionic tissue characterized by enlarged glands with abundant clear or eosinophilic cytoplasm and vacuolization associated with hyperchromatic. Extensive regions of necrosis better microscopic evidence must be sought before making a definitive diagnosis of carcinoma 59. I found a modified ariasstella reaction in paratubal epithelial cells. The glands also show marked cytoplasmic vacuolization.
Endometrio secretor con reaccion arias stella y decidua hemorragica. Results 7301 7400 of 28043 stanford linear accelerator center stanford university, dept. Marisela luzardo aniones 23 octubre 2006 4 sustancias volatiles. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. The ariasstella phenomenon and its diagnostic value in ectopic pregnancy. Ariasstella reaction, also ariasstella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue. A legal procedure for settling a dispute outside the courts, in which the parties select and agree to abide by the decision of a. Ariasstella reaction atypical endometriumendometrial change. Since its first description more than four decades ago, the atypical endometrial change associated with chorionic tissue effect has been widely confirmed in the literature.
The authors present a case of arias stella reaction in the fallopian tube and discuss the differential diagnosis of this condition. Arias stella reaction, also arias stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue. The ariasstella reaction hyperplastic changes of the endometrial epithelium associated with cellular atypia may be seen in uterine or extrauterine pregnancies. Ariasstella reaction of uterine cervix is a benign tumorlike condition caused due to a change in the cervix. Arias stella reaction is due to progesterone primarily. International academy of pathology, monograph n 14. Modified ariasstella reaction in paratubal epithelium. The two patients whose examination exhibited an arias stella reaction were determined to have missed miscarriage, as both had previous ultrasounds that confirmed intrauterine pregnancies. Studies of hormonal levels obtained from the endocrinologic literature demonstrated declines during early pregnancy at the time of the ovaryplacenta changeover. However, it may be influenced by hormonal changes no. Arias stella reaction with a hypersecretorypattern shows strati. Full trisomy 5 in a sample of spontaneous abortion and. That identical cytologic changes may, on occasion, occur outside the endometrium or in nonpregnant women is not as well documented. Arias stella reaction benign atypical endometrial changes associated with chorionic tissue may be seen in a completely normal pregnancy and misdiagnosed as.
Gregory, the arias stella phenomenon and the diagnosis of pregnancy, bjog. Microscopic examination of the left oviduct seg ments revealed zones of hyperplastic endosalpingeal 14 n. Extensive regions of necrosis in curettings causes degenerating carcinoma septic abortion infarcted polyp degenerated submucosal leiomyoma 58. The arias stella reaction is a hormonerelated atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism. The same problem was encountered by cariani and guderian 39 and mccormick and menaciwilliams 40 in endocervical polyps with ariasstella reaction. In general, trisomy 16 is the most frequent chromosomal abnormality, followed by. The arias stella reaction was seen in 26, but features of degeneration were found in arias stella reaction nuclei as well as focal decidual necrosis. Two patients had a history of oral contraceptive use and 15 were pregnant. Both had a history of passing tissue and were diagnosed clinically with incomplete miscarriage. Full trisomy 5 in a sample of spontaneous abortion and arias stella reaction. In an ectopic pregnancy, the uterine endometrium usually responds to the hormonal changes of pregnancy and undergoes focal decidua changes arias stella reaction. In endocervical polyp histologic features similar as in the endometrium.
Ectopic pregnancy human chorionic gonadotropin uterus. Acidifique, gota a gota, con acido clorhidrico 6 moll. Stella reaction where a diagnosis of adenocarcinoma in the peritoneal serosa. In the case of the young couple described in this paper, arias stella reaction was indicated in both cases of miscarriage. Cambios fisicos y cambios quimicos todas las sustancias pueden transformarse. Value of histopathologic examination of uterine products. This report describes the clinical and pathologic findings in nine nonpregnant women whose endometria demonstrated asr. An international journal of obstetrics and gynaecology, 1971, 78, 2, 143wiley online library. Arias stella s undergraduate studies were done first at the san marcos national universitys school of science in peru from 1942 to 1944 and then at the faculty of medicine from 1945 to 1951, from which he earned his bachelors in 1951. Ariasstella reaction in a cervicovaginal smear of a woman. The ariasstella reaction is a hormonerelated atypical endometrial change characterized by hypertrophy and vacuolization of glandular epithelial cells, associated with marked nuclear pleomorphism. We decided to evaluate the subpopulations of treg cells and b7h4 macrophages in eutopic. The ariasstella reaction in early normal pregnancyan.
Arias stella reaction up to 10% of gravid hysterectomy specimens. Historically, 50% of spontaneously expelled abortuses have been thought to be chromosomally abnormal. Ariasstella, j on the importance of the atypical endometrial changes associated with the. Hypersrion is prominent and disarray of somewhat hy perchrom atic nuclei give a pseudoneoplastic appearance. Pdf full trisomy 5 in a sample of spontaneous abortion. This page was last edited on 26 december 2019, at 11. If the ectopic pregnancy miscarries, the uterine decidua may slough off as a cast, but more commonly as fragments mixed with small blood clots. His doctorate was also earned from that faculty in 1959. Ariasstella reaction in fallopian tube epithelium a light. However, the arias stella reaction is exceedingly rare in the fallopian tube, and may be confused with herpetic infection or malignancy. The condition is a normal physiological process of the body, caused due to hormonal response. We report 18 cases of arias stella reaction involving the endocervix with an emphasis on histologic features that can be encountered and result in the misdiagnosis of carcinoma.
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